Clyne has not been seen in action since a pre-season clash with Tranmere Rovers back in July due to a back injury which required minor surgery.
And the 26-year-old hasn’t played competitively since the final day of last season when the Reds beat Middlesbrough.
Youngsters Trent Alexander-Arnold and Joe Gomez have filled in for the experienced England international since then.
But Gomez sustained an ankle injury in the Three Lions’ win over Netherlands last week and is set to miss the “next couple of games”, according to Klopp.
And Gomez’s absence could pave the way for Clyne to make a long-awaited return against Palace, where he started his professional career and made 137 first-team appearances between 2008 and 2012.
Asked about the right-back ahead of Liverpool’s Premier League clash with the Eagles, Klopp said: “He is a top player, 100% per cent, a top professional, a top player.
“Before his injury Clyney played nearly all the games. When we speak about intensity, the only player who didn’t feel it was Clyney, who was up and down all the time and always at a consistent level.
“If we had not the two options with Joe and Trent then we would have missed him like crazy. It was absolutely okay for us as a team.
“You have to prepare for a situation like that but was it 100 per cent clear at the start of the season that Trent would play the season he has played? No.
“Joe had injury problems since I was in so could he play consistently all the time from the beginning? Probably not.
“It was good for us that we could change these two boys in what is a very important position for us. They played a lot of games but a lot of good games.
“There were not many average games from Joe or Trent. They were always involved in a good way. Yes, we missed Clyney but because of the other options it was not that bad.”
Clyne made his under-23s comeback at the end of February, lasting 90 minutes in a 4-0 win over Stoke City, and Klopp believes he is nearing his peak condition.
The German boss added: “We’ve tried to give Clyney as many games as possible after a long time out. I think he’s had three games now.
“It’s not perfect but it’s better than no game. It’s all okay now. You can see in training that everything is there again. We will use him for sure.”